Next Logical Step

Legion : The Next Logical Step Toward a Nationwide Virtual Computer

The coming of giga-bit networks makes possible the realization of a single nationwide virtual computer comprised of a variety of geographically distributed high-performance machines and workstations. To realize the potential that the physical infrastructure provides, software must be developed that is easy to use, supports large degrees of parallelism in applications code, and manages the compl...

Dendritic Cell Immunotherapy, the Next Step in Cancer Treatment

Cancer immunotherapy has gained a lot of interest over the past few years due to the success of immune checkpoint inhibitors in treating cancer (1, 2). Immune checkpoint inhibitors, such as monoclonal antibodies against cytotoxic T-lymphocyte–associated antigen 4 (CTLA-4) and programmed death 1 (PD-1), have been shown to increase survival of patients with advanced cancers (1, 2). These in...

Dendritic Cell Immunotherapy, the Next Step in Cancer Treatment

Cancer immunotherapy has gained a lot of interest over the past few years due to the success of immune checkpoint inhibitors in treating cancer (1, 2). Immune checkpoint inhibitors, such as monoclonal antibodies against cytotoxic T-lymphocyte–associated antigen 4 (CTLA-4) and programmed death 1 (PD-1), have been shown to increase survival of patients with advanced cancers (1, 2). These in...

Dynamic Signal Detection Theory: The next logical step in the evolution of signal detection analysis

Measurement, design, and training programs in human factors often rely on the formal concepts of signal detection theory in order to analyze and interpret the performance of human operators. Following recent work in the response time modeling literature, we propose a generalization of this classical framework that is as simple to apply and yet more powerful, in the sense that it is able to iden...

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